Cocrystal Solubilization in Biorelevant Media and its Prediction from Drug Solubilization
نویسندگان
چکیده
منابع مشابه
Engineering cocrystal solubility, stability, and pH(max) by micellar solubilization.
Cocrystals offer great promise in enhancing drug aqueous solubilities, but face the challenge of conversion to a less soluble drug when in contact with solvent. This manuscript shows that differential solubilization of cocrystal components by micelles can impart thermodynamic stability to otherwise unstable cocrystals. The theoretical foundation for controlling cocrystal solubility and stabilit...
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ژورنال
عنوان ژورنال: Journal of Pharmaceutical Sciences
سال: 2015
ISSN: 0022-3549
DOI: 10.1002/jps.24640